Fig. 5
From: Development of animal model for Bisphosphonates-related osteonecrosis of the jaw (BRONJ)
Representative histologic features of extraction sites(All sacrificed 8 weeks after extraction). a Inflammatory cells(neutrophils) surround necrotic alveolar bone with empty lacunae (Z group, Mn, ×200, sacrificed 8 weeks after extraction). b Sequestra formation apart from alveolar bone with empty lacunae (Z group, Mn, ×100, sacrificed 8 weeks after extraction). c Ulcerative overlying mucosa invaginates into extraction socket, and necrotic bone with empty lacunae on the surface of exposed alveolar bone (Z+D group, Mx, ×50, sacrificed 8 weeks after extraction)