Table 1 Clinical descriptions of the patients with DRONJ
Patient 1 | Patient 2 | Patient 3 | Patient 4 | |
|---|---|---|---|---|
Sex | Male | Male | Female | Male |
Age | 65 | 75 | 79 | 82 |
Primary cancer | Prostate | Prostate | Breast | Prostate |
Concomitant treatment | Docetaxel Corticosteroids | Docetaxel Enzalutamide Corticosteroids | Trastuzumab | Docetaxel Corticosteroids |
ONJ-related underlying diseases | - | Diabetes | Diabetes Rheumatoid arthritis | - |
ONJ site | Mandible posterior | Mandible posterior | Mandible anterior | Maxilla anterior |
Cause of onset | Tooth extraction | Tooth extraction | Spontaneous onset | Tooth extraction, denture |
Number of injections at the time of DRONJ diagnosis | 13 | 10 | 12 | 1 |
A cycle of DMB injection (month) | 1 | 1 | 1.5 | - |
Duration of the DMB treatment before onset (month) | 11 | 6 | 19 | 2 |
Interval between extraction and last DMB injection (month) | 1 | 1 | - | 2 |
Duration of drug holiday before the ONJ surgery (month) | 6 | 1 | 4.5 | - |
Healing period after ONJ surgery (month) | 2 | 2 | 1st surgery: 5 2nd surgery: 5 | a |
Actinomyces finding | Y | Y | Y | - |
DRONJ status at the end of follow up | Stabilization | Stabilization | Stabilization | Unknown/death |