Prognostic factors of oral squamous cell carcinoma: the importance of recurrence and pTNM stage

Maxillofacial Plastic and Reconstructive Surgery

Table 1 Univariate analysis of the factors influencing the survival rate of OSCC

Factor	n (%)	DSD		DSS (%)	Hazard ratio	P value
Sex					1.07	.79
	Male	67	112	59.8
	Female	33	56	58.9
Age (year)					1.09	.82
	≥ 50	87	147	59.2
	< 50	13	21	61.9
Smoking					0.855	.52
	Yes	48	78	61.5
	No	52	90	57.8
Alcohol					0.787	.35
	Non or light	57	101	56.4
	Heavy	43	67	64.2
TNM stage					12.85	< .001
	Stage I, II	59	64	92.2
	Stage III, IV	41	104	39.4
NM					3.78	< .001
	Positive	10	24	41.7
	Negative	90	144	62.5
DOI					3.86	< .001
	< 5	44	54	81.5
	≥ 5	56	114	49.1
PNI					1.393	.141
	Yes	8	17	47.1
	No	92	151	60.9
LVI					2.07	.016
	Yes	10	24	41.7
	No	90	144	62.5
ND					3	.537
	Yes	58	110	40.8
	No	71	58	73.2
RT					2.41	< .001
	Yes	32	73	43.8
	No	68	95	71.6
Site						.179
	Lip	1	2	50
	Tongue	21	38	55.3
	FOM	12	15	80
	Mn gingiva	21	39	53.8
	Mx gingiva	12	21	57.14
	Mn vestibule	1	2	50
	Mx vestibule	0	0
	RMT	7	11	63.6
	Hard palate	0	1	0
	Soft palate	1	3	33.3
	BM	21	27	77.8
	PIOS	3	9	33.3
Recurrence					14.07	< .001
	Yes	20	81	24.7
	No	80	87	92
Differentiation						.004
	Well	51	77	66.2
	Moderate	49	87	56.3	1.53
	Poor	0	4	0	8.71

DSD disease-specific death, DSS disease-specific survival, NM neck metastasis, DOI depth of invasion, PNI perineural invasion, LVI lymphovascular invasion, ND neck dissection, RT radiotherapy, FOM floor of mouth, Mn. mandible, Mx. maxilla, RMT retromolar trigone, BM buccal mucosa, PIOS primary intraosseous squamous cell carcinoma)