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Table 4 Immunohistochemistry analysis of collagen type I, OPG and RANKL

From: Combined effect of bisphosphonate and recombinant human bone morphogenetic protein 2 on bone healing of rat calvarial defects

Antibody Time/week Groups
Group 1 Group 2 Group 3 Group 4
Collagen type I 2 ++ +++ +++ +
4 ++ ++ ++ ++
8 +++ +++ +++ +
2 ++ ++ ++ +
OPG 4 +/++ ++ +/++ +
8 ++ ++ +++ +
2 ++ ++ + ++
RANKL 4 ++ +++ −/+ ++
8 + + + ++
  1. (−; no immunoreactivity, +; weak immunoactivity, ++; moderate immunoactivity, +++; strong immunoactivity, Abbreviations: OPG osteoprotegerin, RANKL receptor activator nuclear factor κB ligand)