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Table 2 Summary of previous case reports on oral mucosal pigmentation associated with imatinib therapy

From: Hyperpigmentation of the hard palate mucosa in a patient with chronic myeloid leukaemia taking imatinib

Author(s), year Duration of treatment with imatinib Dosage (mg/dose) Age and sex of patient Site(s) affected Histological findings Condition treated
Singh and Bakhshi 2007 [15] 4 years 300 13 F Gingivae, teeth Clinical diagnosis only CML
Lewis, 2009 [18] Unknown 800 70 M Palate Melanin and haemosiderin deposits in lamina propria CML
Mcpherson et al. 2009 [38] 6 years Unknown 59 F Gingivae, toes, fingernails Clinical diagnosis only CML
Wong et al. 2011 [19] 3 months Unknown 43 F Palate Melanin deposits in lamina propria CML
Mattsson et al. 2011 [20] 5 years
5 years
5 years
400
400
400
66 F
66 F
64 F
Palate
Palate
Palate
Melanin deposits in lamina propria
Clinical diagnosis only
Metastatic gastrointestinal stromal tumour
CML
CML
Li et al. 2012 [3] 4 years
10 years
5 years
400
400
400
64 M
53 M
29 F
Palate
Palate
Palate
Melanin and haemosiderin deposits in lamina proria CML
CML
Pelvic fibromatosis
Resende et al. 2012 [21] 5 years 600 38 M Palate, nose, earlobes Clinical diagnosis only Post-haematopoietic stem
Cells transplant
Roeker and Wolanskyj 2014 [22] 6 years Unknown 65 F Palate Clinical diagnosis only CML
Song and Kang 2014 [23] Unknown Unknown 58 M Palate, nose Clinical diagnosis only CML
Lyne et al. 2015 [24] 13 years 400–600 58 F Palate Haemosiderin deposits in lamina propria CML
Romeo et al. 2015 [39] 11 years 400 72 F Palate Brown spherical bodies located within the lamina propria CML
  1. CML chronic myeloid leukaemia