Table 2 Summary of previous case reports on oral mucosal pigmentation associated with imatinib therapy
Author(s), year | Duration of treatment with imatinib | Dosage (mg/dose) | Age and sex of patient | Site(s) affected | Histological findings | Condition treated |
|---|---|---|---|---|---|---|
Singh and Bakhshi 2007 [15] | 4 years | 300 | 13 F | Gingivae, teeth | Clinical diagnosis only | CML |
Lewis, 2009 [18] | Unknown | 800 | 70 M | Palate | Melanin and haemosiderin deposits in lamina propria | CML |
Mcpherson et al. 2009 [38] | 6 years | Unknown | 59 F | Gingivae, toes, fingernails | Clinical diagnosis only | CML |
Wong et al. 2011 [19] | 3 months | Unknown | 43 F | Palate | Melanin deposits in lamina propria | CML |
Mattsson et al. 2011 [20] | 5 years 5 years 5 years | 400 400 400 | 66 F 66 F 64 F | Palate Palate Palate | Melanin deposits in lamina propria Clinical diagnosis only | Metastatic gastrointestinal stromal tumour CML CML |
Li et al. 2012 [3] | 4 years 10 years 5 years | 400 400 400 | 64 M 53 M 29 F | Palate Palate Palate | Melanin and haemosiderin deposits in lamina proria | CML CML Pelvic fibromatosis |
Resende et al. 2012 [21] | 5 years | 600 | 38 M | Palate, nose, earlobes | Clinical diagnosis only | Post-haematopoietic stem Cells transplant |
Roeker and Wolanskyj 2014 [22] | 6 years | Unknown | 65 F | Palate | Clinical diagnosis only | CML |
Song and Kang 2014 [23] | Unknown | Unknown | 58 M | Palate, nose | Clinical diagnosis only | CML |
Lyne et al. 2015 [24] | 13 years | 400–600 | 58 F | Palate | Haemosiderin deposits in lamina propria | CML |
Romeo et al. 2015 [39] | 11 years | 400 | 72 F | Palate | Brown spherical bodies located within the lamina propria | CML |