Fig. 1

Photomicrographs of mouse liver, hematoxylin and eosin stain. a Normal mouse liver. b Mouse liver treated with DCE-2.5, denoting hypertrophic hepatocytes with increased nuclear heterochromatism. c Mouse liver treated with DCE-5 had hypertrophic hepatocytes, which formed thick hepatic cords. d In the livers of mice treated with DCE-10, hepatocytes were slightly shrunken and aligned, and sinusoidal spaces were enlarged