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Table 1 The association between the risk factors and development of OF

From: Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study

Variables Case (%) Control (%) Odds ratio (CI = 95%) P value Adjusted ORa (95% CI) P value
Sex female (male, reference category) 171 (53) 204 (51) 1.081 (0.8061.450) 0.60354 1.007 (0.7421.367) 0.964131
History of abortion/miscarriage 42 (13) 28 (7) 1.986 (1.2013.283) 0.007475 1.339 (0.7612.355) 0.311026
Consanguineous marriage 119 (36) 93 (23) 1.926 (1.3932.662) 0.00735 1.854 (1.3292.586) 0.0275
Systemic diseases 36 (11) 32 (8) 1.443 (0.8742.380) 0.151417 1.307 (0.7732.211) 0.318197
Medication during pregnancy 122 (38) 124 (31) 1.358 (0.9971.850) 0.05254 1.339 (0.9711.847) 0.074891
Complications during pregnancy 92 (29) 88 (22) 1.412 (1.0071.980) 0.045517 1.293 (0.9011.856) 0.162789
Maternal age (years) < 25 43 (14) 48 (12) 1.483 (0.9042.432) 0.118696 1.608 (0.9522.717) 0.075617
26–30 (reference) 87 (27) 136 (34) 1 1 -
30–35 102 (31) 132 (33) 1.063 (0.9391.204) 0.335031 1.062 (0.9311.213) 0.369834
> 35 91 (28) 84 (21) 1.151 (1.0421.272) 0.005646 1.139 (1.0271.264) 0.01355
Paternal age (years) < 25 29 (9) 44 (11) 1.023 (0.5841.792) 0.93643 1.092 (0.6021.982) 0.771544
26–30 (reference) 67 (21) 104 (26) 1 1
30–35 122 (38) 144 (36) 1.098 (0.9641.251) 0.158797 1.098 (0.9581.260) 0.179591
> 35 105 (32) 108 (27) 1.106 (0.9981.225) 0.053716 1.105 (0.9931.230) 0.067299
Birth order 1st (reference) 158 (49) 156 (39) 1 1
2nd 83 (26) 140 (35) 0.760 (0.6380.906) 0.002204 0.789 (0.6560.948) 0.011335
3rd 51 (16) 72 (18) 0.887 (0.7711.021) 0.096105 0.914 (0.7911.057) 0.225932
4th and higher 31 (9) 32 (8) 0.997 (0.8701.142) 0.963656 0.988 (0.8561.142) 0.872614
Total 323(100) 400 (100) -
  1. C
  2. aOR is adjusted for all other factors in the table