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Table 2 QUADAS-2 assessment of the risk bias and applicability for the included articles in this review

From: Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review

Study

Risk of bias

Applicability concerns

Patient selection

Index test

Reference standard

Flow and timing

Patient selection

Index test

Reference standard

Byun et al. [15]

?

+

+

+

+

+

+

Langevin et al. [16]

+

+

+

+

+

+

+

Gai et al. [17]

+

?

+

+

+

+

+

He et al. [18]

+

+

+

+

+

+

+

Farag et al. [19]

+

+

+

+

+

+

+

  1. + Low risk; - High Risk; ? Unclear