Efficacy and safety of rhBMP/β-TCP in alveolar ridge preservation: a multicenter, randomized, open-label, comparative, investigator-blinded clinical trial

Maxillofacial Plastic and Reconstructive Surgery

Table 2 Changes in alveolar bone height (mm) at week 12

	Test group (N = 41)	Control group (N = 43)
Change from baseline at week 12
Mean ± SD	− 0.51 ± 0.94	− 1.50 ± 1.26
LS mean ± SE	− 0.50 ± 0.20	− 1.42 ± 0.19
Median	− 0.17	− 1.32
Min, max	− 4.52, 0.44	− 5.63, 0.25
p value^*	< 0.0001 (w)	< 0.0001 (w)
LS mean difference (SE) with control group	0.92 (0.25)
95% CI for the LS mean difference	[0.43, 1.41]
p value^†	0.0004

SD standard deviation, LS mean least-square mean, SE standard error, CI confidence interval
^*Testing for within-treatment group (paired t test (t) or Wilcoxon’s signed-rank test (w))
^†Testing for between-treatment group (ANCOVA model with baseline value and trial center as covariates)