Efficacy and safety of rhBMP/β-TCP in alveolar ridge preservation: a multicenter, randomized, open-label, comparative, investigator-blinded clinical trial

Maxillofacial Plastic and Reconstructive Surgery

Table 4 Changes in alveolar bone width for 50% extraction socket length (mm) at week 12

	Test group (N = 41)	Control group (N = 43)
Change from baseline at week 12
Mean ± SD	− 0.33 ± 0.53	− 1.81 ± 2.05
LS mean ± SE	− 0.19 ± 0.26	− 1.69 ± 0.25
Median	− 0.05	− 1.29
Min, max	− 2.02, 0.84	− 10.51, 0.00
p value^*	< 0.0001 (w)	< 0.0001 (w)
LS mean difference (SE) with control group	1.50 (0.32)
95% CI for the LS mean difference	[0.86, 2.14]
p value^†	< 0.0001

SD standard deviation, LS mean least-square mean, SE standard error, CI confidence interval
^*Testing for within-treatment group (paired t test (t) or Wilcoxon’s signed-rank test (w))
^†Testing for between-treatment group (ANCOVA model with baseline value and trial center as covariates).