Table 2 Frequency of side effects in total

Fatigue

No

238

21.0%

Yes

894

79.0%

Malaise

No

306

27.0%

Yes

826

73.0%

Headache

No

445

39.3%

Yes

687

60.7%

Body pain

No

327

28.9%

Yes

805

71.1%

Fever

No

492

43.5%

Yes

640

56.5%

Chills and shiver

No

585

51.7%

Yes

547

48.3%

Local pain in hand

No

256

22.6%

Yes

876

77.4%

Pain in foot

No

650

57.4%

Yes

482

42.6%

Loss of appetite

No

716

63.3%

Yes

416

36.7%

Dizziness

No

691

61.0%

Yes

441

39.0%

Arthralgia

No

625

55.2%

Yes

507

44.8%

Insomnia

No

728

64.3%

Yes

404

35.7%

Bradycardia

No

811

71.6%

Yes

321

28.4%

Crump/abdominal pain

No

903

79.8%

Yes

229

20.2%

Chest pain

No

875

77.3%

Yes

257

22.7%

Diarrhea

No

971

85.8%

Yes

161

14.2%

Cough

No

930

82.2%

Yes

202

17.8%

Shortness of breath

No

936

82.7%

Yes

196

17.3%

Vision disorders

No

934

82.5%

Yes

198

17.5%

Jaw pain

No

992

87.6%

Yes

140

12.4%

Earache

No

1003

88.6%

Yes

129

11.4%

Vomiting

No

1018

89.9%

Yes

114

10.1%

Cellulitis warmth and swollen armpit glands

No

1034

91.3%

Yes

98

8.7%

Redness and itch

No

1000

88.3%

Yes

132

11.7%

Blurred vision

No

993

87.7%

Yes

139

12.3%

Diplopia

No

1062

93.8%

Yes

70

6.2%

Dysphagia

No

1060

93.6%

Yes

72

6.4%

Facial numbness

No

1112

98.2%

Yes

20

1.8%

Anesthesia (face/body)

No

1056

93.3%

Yes

76

6.7%

Tachycardia

No

1089

96.2%

Yes

43

3.8%

Anaphylactic shock

No

1121

99.0%

Yes

11

1.0%

Thrombosis and blood-clotting

No

1110

98.1%

Yes

22

1.9%

Oral bleeding

No

1116

98.6%

Yes

16

1.4%

Nasal bleeding

No

1095

96.7%

Yes

37

3.3%

Seizure

No

1122

99.1%

Yes

10

0.9%

Faint

No

1100

97.2%

Yes

32

2.8%

Optic neuritis

No

1104

97.5%

Yes

28

2.5%

Speech disorders

No

1098

97.0%

Yes

34

3.0%