Table 3 Dimensional changes of the alveolar ridge after ARP procedures with CBXs. Data are presented as Mean ± SD

Barone et al., 2008

Extraction alone

CBX

covered by a collagen membrane

-

Change in horizontal ridge width

- 4.5 ± 0.8 mm

- 2.5 ± 1.2 mm*

-

Change in vertical ridge height at mid-buccal aspect

- 3.6 ± 1.5 mm

- 0.7 ± 1.4 mm*

-

Change in vertical ridge height at mid-lingual aspect

- 3.0 ± 1.6 mm

- 0.4 ± 1.3 mm*

-

Change in vertical ridge height at mesial aspect

- 0.4 ± 1.2 mm

- 0.2 ± 0.8 mm

-

Change in vertical ridge height at distal aspect

- 0.5 ± 1.0 mm

- 0.4 ± 0.8 mm

-

Timepoint of analyses: 7 months

Barone et al., 2013

Extraction alone

CBX

covered by a collagen

membrane

-

Change in bone horizontal dimensions

- 3.6 ± 0.72 mm

- 1.6 ± 0.55 mm

-

Change in bone vertical dimensions at mesial aspect

- 1.0 ± 0.7 mm

- 0.3 ± 0.76 mm

Change in bone vertical dimensions at buccal aspect

- 2.1 ± 0.6 mm

- 1.1 ± 0.96 mm

-

Change in bone vertical dimensions at distal aspect

- 1.0 ± 0.8 mm

- 0.3 ± 0.85 mm

-

Change in bone vertical dimensions at lingual aspect

- 2.0 ± 0.73 mm

- 0.9 ± 0.98 mm

-

Timepoint of analyses: 4 months

Festa et al., 2013

Extraction alone

CBX

associated with a

soft cortical membrane

-

Horizontal ridge width

change

- 3.7 ± 1.2 mm

- 1.8 ± 1.3 mm*

-

Change in vertical ridge height at mid-buccal aspect

- 3.1 ± 1.3 mm

- 0.6 ± 1.4 mm*

-

Vertical ridge height changes at mid-lingual aspect

- 2.4 ± 1.6 mm

- 0.5 ± 1.3 mm*

-

Vertical ridge height change

at mesial aspect

- 0.4 ± 1.2 mm

- 0.3 ± 0.8 mm

-

Vertical ridge height change

at distal aspect

- 0.5 ± 1.0 mm

- 0.4 ± 0.8 mm

-

Timepoint of analyses: 6 months

Barone et al., 2014

-

CBX

covered by a collagen membrane in association with a full-tickness mucoperiosteal flap procedure

CBX

covered by a collagen membrane in association with flapless procedure

Change in

buccal–lingual width

-

- 3.5 ± 0.9 mm**

- 1.7 ± 0.6 mm

Change in vertical bone level at buccal aspect

-

- 0.6 ± 0.7 mm**

- 1.1 ± 0.9 mm

Change of vertical bone level at mesial aspect

-

- 0.4 ± 0.5 mm

- 0.3 ± 0.7 mm

Change of vertical bone level at distal aspect

-

- 0.5 ± 0.6 mm

- 0.3 ± 0.9 mm

Change in vertical bone level at lingual–palatal aspect

-

- 0.6 ± 0.7 mm

- 0.9 ± 1.0 mm

Timepoint of analyses: 3 months

Barone et al., 2017

Spontaneous healing

Collagenated CBX

covered by a collagen membrane

ABX

covered by a collagen membrane

Change in

buccal–lingual width

- 3.60 ± 0.72 mm

- 0.93 ± 1.26 mm*

- 1.33 ± 0.71 mm*

Change in vertical bone level at buccal aspect

- 2.10 ± 0.66 mm

- 0.57 ± 1.54 mm*

- 0.30 ± 1.28 mm*

Change in vertical bone level at lingual–palatal aspect

- 2.03 ± 0.72 mm

- 1.00 ± 1.17 mm*,**

0.67 ± 2.54 mm*

Change of vertical bone level at mesial–distal aspect

- 0.15 ± 0.38 mm

- 1.08 ± 1.37 mm*

- 0.90 ± 1.26 mm

Timepoint of analyses: 3 months

Marconcini et al., 2018

Spontaneous healing

CBX

covered by a collagen membrane

ABX

covered by a collagen membrane

Change in

marginal bone height

- 0.69 ± 0.43 mm (1y)

- 1.30 ± 0.59 mm (2y)

- 1.69 ± 0.43 mm (4y)

- 0.53 ± 0.54 mm (1y)*

- 0.80 ± 0.36 mm (2y)*

- 0.96 ± 0.51 mm (4y)*

- 0.28 ± 0.37 mm (1y)*

- 0.60 ± 0.48 mm (2y)*

- 0.75 ± 0.37 mm (4y)*

Timepoint of analyses: 1, 2 and 4 years

Roberto et al., 2021

-

CBX

covered by a collagen sheet

Collagen sponge

Change in alveolar ridge width

-

- 2.7 ± 0.9 mm**

- 3.9 ± 1.4 mm

Timepoint of analyses: 2–3 months