Fig. 7
From: The effect of 4-hexylresorcinol on xenograft degradation in a rat calvarial defect model
Histological exam. a The bovine bone implant was encapsulated by a fibrotic capsule, and no sign of degradation was observed. b The animal that received 4-hexylresorcinol-incorporated bovine bone implants showed little residual grafting and still experienced a large bony defect. New bone formation was observed only in the cutting edge of the calvarial bone. c Another animal bovine bone implant incorporated with 4-hexylresorcinol showed focal degradation of the graft. Most grafts still occupied the bony defect. d New bone regeneration (asterisk) over the bovine implant was observed in some animals that received a bovine bone implant. The regenerated bone directly contacted with the implant (arrow heads). e High magnification view of (b). Residual graft was stained with violet color (asterisk), and multinucleated giant cells (arrow heads) were observed. Highly developed vascular channels were also observed. Interestingly, some giant cells appeared to transform into endothelial cells (arrow head). f High magnification view of (c). Focal dissolution of implants with reparative calcification was observed