Table 2 Antibodies used in the study

Proliferation-related proteins

11

Ki-67^*, PCNA^a, CDK4^a, PLK4^a, lamin A/C, MPM2^a, cyclin D2, p14, p16^a, p21^a, p27^a

cMyc/MAX/MAD network proteins

3

cMyc^a, MAX^a, MAD^a

p53/Rb/E2F signaling proteins

5 (1)

p53, Rb-1^#, E2F-1^a, MDM2^a, (CDK4)

Wnt/β-catenin signaling proteins

5

Wnt1^a, β-catenin^a, APC^a, snail^a, TCF-1^a

Epigenetic modification proteins

6

DMAP1^a, histone H1^a, KDM4D^$, HDAC-10^$, MBD4^a, DNMT1^a

Protein translation proteins

5

DOHH^a, DHS^a, elF5A-1^$, elF5A-2^$, eIF2AK3^a

Growth factor proteins

16

FGF-1^a, FGF-2^a, HGF-1^a, TGF-β1^#, TGF-β2, SMAD4^a, IGF-1^a, IGFIIR^a, GH^a, GHRH^a, HER1^a, HER2^a, Erβ^a, insulin^@, Met^a, CTGF^a

RAS signaling proteins

12

NRAS^$, KRAS^$, STAT3^a, SOS-1^a, SOS-2^a, RAF-B^a, JNK-1^a, ERK1^a, p-ERK^$, MEKK^a, pAKT1/2/3, PI3K^a

NFkB signaling proteins

12 (2)

NFkB^a, IKK^a, GADD45^a, GADD153, MDR^a, mTOR^@, p38^a, p-p38^a, AMPK, PGC-1α, (ERK1^a, p-ERK^a)

Cellular stress and adaptation proteins

16 (8)

LC3^a, PLC-β2^a, PKC^a, p-PKC^a, AKAP^a, NFAT5^a, leptin^a, HXK II^a, (pAKT1/2/3^a, p38^a, GADD45^a, PI3K^a, MDM2^a, mTOR^a, ERK-1^a, MDR^a)

Inflammatory proteins upregulated

13 (2)

IL-8, IL-12^a, CD31^a, COX1, α1-AT, LL-37, hepcidin^a, (TGF- β1^#, TGF- β2), MMP-1^a, MMP-3^a, MMP-9^a, MMP-10^a

Inflammation proteins downregulated

17

TNFα^@, IL-1^a, IL-6^a, IL-10^a, IL-28^a, M-CSF^a, lysozyme^a, COX-2^a, CD56^a, CD68^a, CD99^a, cathepsin C^a, cathepsin G^a, CRP-1^a, lactoferrin^a, MMP-2^a, MMP-12^a

Cellular differentiation proteins

11

TGase-2^$, p63^$, caveolin^a, Jagged2^a, Notch 1^a, GLI-1^a, Muc1^a, Muc4^a, AP-1^a, SP-1^a, SP-3^a

Antioxidant and protection-related

11 (2)

HO-1^a, SOD-1^a, GST-1^a, NOS-1^$, LC3^a, HSP-27^a, HSP-70^a, HSP-90^a, (leptin^a, hepcidin), NRF2^a

p53-mediated apoptosis proteins

13 (2)

BCL2^a, BAX^a, BAD^a, BAK^a, BID^a, AIF^a, APAF-1^a, caspase 9^a, c-caspase 9^a, PARP^a, c-PARP^a(p53^a, MDM2^a)

FAS-mediated apoptosis proteins

9 (1)

FASL^a, FAS^a, FADD^a, FLIP^a, caspase 8^a, caspase 3^a, c-caspase 3^a, (BID)

Oncogenic proteins

12 (4)

PTEN^&, DMBT-1^a, CEA^a, 14–3-3^a, survivin^@, YAP^a 1, TERT^a, (pAKT1/2/3^a, MBD4^a, Muc1^a, Muc4^a), ATM^a

Angiogenesis-related proteins

17 (4)

HIF^&, VEGF-A^a, VEGF-C^a, angiogenin^$, LYVE-1^a, CMG2^$, vWF^$, FLT-4^$, ET-1^a, PAI-1^a, plasminogen, PDGF-A^a, VCAM^a, (COX-1^a, leptin^a, CD31, FGF-2^a)

Control housekeeping proteins

3

α-tubulin^a, β-actin^a, GAPDH^a

Total

223 (26)

tTotal 197 antibodies