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Table 1 Characteristics of PD-L1/p53/CK17 expression in patients with oral squamous cell carcinoma

From: PD-L1 expression correlated with p53 expression in oral squamous cell carcinoma

Characteristics

 

PD-L1 expression in TCs

p53 expression

CK17 expression

Cases

Positive ( ≥5%)

Negative (<5%)

P value

Positive ( ≥10%)

Negative (<10%)

P value

Strong ( ≥60%)

Weak (<60%)

P value

Gender

Male

29

14

15

1.00

20

9

0.37

4

25

0.27

Female

20

10

10

 

11

9

 

6

14

 

Age

<65 years

22

12

13

1.00

15

10

0.76

5

20

1.00

>65 years

27

12

12

 

16

8

 

5

19

 

T stage

T1–T3

34

15

19

 

18

16

 

5

29

0.12

T4

14

8

6

0.52

12

2

0.049*

5

9

 

Unknown

1

1

0

 

1

0

 

0

1

 

N stage

N (+)

20

10

10

 

13

7

 

4

16

 

N (-)

28

13

15

1.00

17

11

1.00

6

22

1.00

Unknown

1

1

  

1

   

1

 

M stage

M0

48

22

25

 

29

18

 

0

1

 

M1

0

1

0

0.47

1

0

1.00

10

37

1.00

Unknown

1

1

0

 

1

0

 

0

1

 

TNM stage

I–III

30

13

17

 

15

15

 

4

26

 

IV

18

10

8

0.55

15

3

0.03*

6

12

0.14

Unknown

1

1

0

 

1

0

 

0

1

 

Differentiation

Well

35

19

16

 

20

15

 

8

27

 

Moderate

11

4

7

0.54

8

3

0.31

1

10

0.47

Poor

3

1

2

 

3

0

 

1

2

 

Mode of invasion

Grade 1

3

2

1

 

2

1

 

2

1

 

Grade 2

9

4

5

 

3

6

 

1

8

 

Grade 3

17

9

8

0.96

11

6

0.21

3

14

0.37

Grade 4C

16

7

9

 

11

5

 

3

13

 

Grade 4D

4

2

2

 

4

0

 

1

3

 

PD-L1 expression in TCs

Positive

24

 

21

10

0.0009*

17

22

0.17

Negative

25

3

15

 

7

3

 

PD-L1 expression in TILs

Positive

28

21

7

< .0001*

21

7

0.07

20

19

0.15

Negative

21

3

18

 

11

10

 

8

2

 

p53 expression

Positive

31

21

10

0.0009*

 

22

17

0.06

Negative

18

3

15

 

9

1

 

CK17 expression

Weak

39

17

22

0.17

22

17

0.06

 

Strong

10

7

3

 

9

1

 
  1. P value : χ2 test and Fisher's exact test were used. *P<0.05 was defined as significantly different in statistical analysis
  2. Unknown includes those cases with Tx, Nx, Mx and TNM status and they were excluded from statistical analysis