ISQ | Group | p value | ||||||
---|---|---|---|---|---|---|---|---|
a: nicotine | b: nicotine+l-arg | c: no nicotine no l-arg | Total | a, b | a, c | b, c | ||
Baseline | 78.0 ± 2.6 | 73.5 ± 2.3 | 72.2 ± 3.1 | 0.001 | 0.009 | 0.001 | 0.609 | |
Week 1 | 74.8 ± 4.5 | 67.4 ± 8.3 | 65.4 ± 4.1 | 0.035 | 0.077 | 0.048 | 0.970 | |
Week 2 | 68.0 ± 7.3 | 61.6 ± 6.7 | 68.5 ± 4.17 | 0.072 | – | – | – | |
Week 3 | 77.3 ± 4.5 | 63.5 ± 4.9 | 63.5 ± 9.0 | 0.001 | 0.003 | 0.003 | > 0.999 | |
Week 4 | 80.0 ± 3.7 | 68.1 ± 9.5 | 75.6 ± 6.9 | 0.011 | 0.009 | 0.452 | 0.114 | |
p value | Linear | 0.158 | 0.213 | 0.616 | ||||
Quadratic | < 0.001 | 0.016 | < 0.001 |