Efficacy and safety of rhBMP/β-TCP in alveolar ridge preservation: a multicenter, randomized, open-label, comparative, investigator-blinded clinical trial

Maxillofacial Plastic and Reconstructive Surgery

Table 3 Changes in alveolar bone width for 75% extraction socket length (mm) at week 12

	Test group (N = 41)	Control group (N = 43)
Change from baseline at week 12
Mean ± SD	− 0.33 ± 0.46	− 0.78 ± 1.12
LS mean ± SE	− 0.23 ± 0.15	− 0.70 ± 0.15
Median	− 0.08	− 0.32
Min, max	− 1.97, 0.00	− 5.22, 0.00
p value^*	< 0.0001 (w)	< 0.0001 (w)
LS mean difference (SE) with control group	0.46 (0.19)
95% C.I for the LS mean difference	[0.09, 0.84]
p value^†	0.0152

SD standard deviation, LS mean least-square mean, SE standard error, CI confidence interval
^*Testing for within-treatment group (paired t test (t) or Wilcoxon’s signed-rank test (w))
^†Testing for between-treatment group (ANCOVA model with baseline value and trial center as covariates)