Efficacy and safety of rhBMP/β-TCP in alveolar ridge preservation: a multicenter, randomized, open-label, comparative, investigator-blinded clinical trial

Maxillofacial Plastic and Reconstructive Surgery

Table 5 Changes in alveolar bone width for 25% extraction socket length (mm) at week 12

	Test group (N = 41)	Control group (N = 43)
Change from baseline at week 12
Mean ± SD	− 1.08 ± 2.11	− 4.13 ± 3.56
LS Mean ± SE	− 0.93 ± 0.50	− 3.96 ± 0.48
Median	− 0.28	− 3.04
Min, max	− 9.87, 0.00	− 13.84, 0.00
p value^*	< 0.0001 (w)	< 0.0001 (w)
LS mean difference (SE) with control group	3.03 (0.61)
95% CI for the LS mean difference	[1.81, 4.24]
p value^†	< 0.0001

SD standard deviation, LS mean least-square mean, SE standard error, CI confidence interval
^*Testing for within-treatment group (paired t test (t) or Wilcoxon’s signed-rank test (w))
^†Testing for between-treatment group (ANCOVA model with baseline value and trial center as covariates)