- Research
- Open Access
Qualitative correlation between postoperatively increased vertical dimension and mandibular position in skeletal class III using partial-least-square path modeling
- Na-Ri Kim†^{1},
- Soo-Byung Park†^{1},
- Jihyun Lee^{1},
- Youn-Kyung Choi^{1},
- Sang Min Shin^{2},
- Yong-Seok Choi^{3} and
- Yong-Il Kim^{1, 4, 5}Email author
https://doi.org/10.1186/s40902-017-0114-4
© The Author(s). 2017
- Received: 1 March 2017
- Accepted: 19 April 2017
- Published: 5 June 2017
Abstract
Background
This study constructed a partial-least-square path-modeling (PLS-PM) model and found the pathway by which the postsurgical vertical dimension (VD) affects the extent of the final mandibular setback on the B point at the posttreatment stage for the skeletal class III surgery-first approach (SFA).
Methods
This study re-analyzed the data from the retrospective study by Lee et al. on 40 patients with skeletal class III bimaxillary SFA. Variables were obtained from cone beam computed tomography (CBCT)-generated cephalograms. Authors investigated all variables at each time point to build a PLS-PM model to verify the effect of the VD on the final setback of the mandible.
Results
From PLS-PM, an increase in VD_{10} was found to decrease the absolute value of the final setback amount of the mandible, which reflects the postsurgical physiological responses to both surgery and orthodontic treatment, which, in turn, can be interpreted as an increase in postoperative mandibular changes.
Conclusions
To resolve the issue of collinear cephalometric data, the present study adopted PLS-PM to assess the orthodontic treatment. From PLS-PM, it was able to summarize the effect of increased postsurgery occlusal vertical dimension on the increased changeability of the B point position at the posttreatment stage.
Keywords
- Surgery-first approach
- Vertical dimension
- Mandibular position
- Pathway
- Modeling
Background
Many clinical studies in dental research have used multiple regression analysis to find correlations between the predictor and the response variables. However, one possible problem with this approach is the collinearity between or among predictors. In statistics, when there are more than two predictors that are highly correlated, it is called collinearity [1, 2]. The interpretation of the statistical results from multiple regression models might be distorted by collinearity. The variables in research are mathematically coupled, so they are statistically collinear [2, 3]. In the fields of orthodontic and orthognathic surgery, several anatomic landmarks’ variables, obtained from each part of the craniofacial structure, might be mutually related, because each segment moves simultaneously with those landmarks during orthodontic or orthognathic procedures. Therefore, some variables from orthodontic research should be considered to detect collinearity.
Partial-least-square (PLS) modeling has been used for success factor studies in marketing and for estimating several satisfaction index models [4, 5]. PLS modeling is also often used as an alternative to conventional statistical modeling methods. Unlike conventional modeling methods, which rely on covariance decomposition, PLS is a variance-based method that does not carry the covariance assumptions. Therefore, PLS is less sensitive to the problems arising from collinearity [6, 7].
Tu and co-workers attempted to resolve the collinearity problems in periodontal research by using PLS regression and applied PLS path modeling to describe the relationship between baseline characteristics of infrabony lesions and the treatment outcomes [3]. In the fields of orthodontics and orthognathic, a few studies have considered the problems induced from the assessment of treatment outcomes by PLS path modeling (PLS-PM) [8].
The aim of this study was to re-analyze collinear data from the cephalometric study by Lee et al. [9] using PLS-PM, to construct a PLS-PM model, and finally to find the pathway whereby the postsurgical vertical dimension (VD at T _{1}) affects the extent of the final mandibular setback on the B point at the posttreatment stage (T _{2}) for the skeletal class III surgery-first approach (SFA).
Methods
We re-analyzed the data from the retrospective study by Lee and co-workers [9] on 40 patients with skeletal class III SFA (16 males, 24 females; mean age, 22.6 ± 4.0 years) in the Department of Oral and Maxillofacial Surgery and the Department of Orthodontics, at Pusan National University Hospital. In accordance with SFA procedures, all patients received LeFort I osteotomy and mandibular setback sagittal split ramus osteotomy (SSRO). This study was reviewed and approved by the Institutional Review Board of Pusan National University Hospital (E-2014021).
Model-relevant landmarks, planes, distances, and indicators
Terms | Definitions |
---|---|
Landmarks | |
B point (B) | Innermost curvature from chin to alveolar bone junction |
Menton (Me) | Lowest point on symphysis of mandible |
Pogonion (Pog) | Most anterior point on contour of chin |
A point (A) | Innermost curvature from maxillary anterior nasal spine to crest of maxillary alveolar process |
Coronoid process (Cp) | Tip of coronoid process |
Planes | |
Frankfurt-horizontal (FH) plane | Plane formed by right Po and both sides of Or |
Midsagittal reference (MSR) plane | Perpendicular to FH plane and passing through Na and Ba |
S-perpendicular plane (S-perp) | Perpendicular to FH and MSR planes and passing through Sella |
Distances | |
B point to S-perp (B^{s}) | Distance from B point to S-perpendicular plane |
Menton to S-perp (Me^{s}) | Distance from menton to S-perpendicular plane |
Pogonion to FH plane (Pog^{f}) | Distance from pogonion to FH plane |
A point to S-perp (A^{ s }) | Distance from A point to S-perpendicular plane |
Coronoid process to FH plane (Cp^{f}) | Distance from tip of coronoid process to FH plane |
Occlusal vertical distance (VD) | Distance from mesial contact of upper 1st molar to that of lower 1st molar |
Indicators | |
Final setback of B point \( \left({\mathrm{B}}_{20}^{\mathrm{s}}\right) \) | B^{s} changes from T _{0} to T _{2}, combined effects of surgery and orthodontic treatment over presurgical (T _{0}) to posttreatment period (T _{2}) |
Surgical setback of B point \( \left({\mathrm{B}}_{10}^{\mathrm{s}}\right) \) | B^{s} changes from T _{0} to T _{1}, surgical effects measured over presurgical (T _{0}) to postsurgical period (T _{1}) |
Surgical setback of menton \( \left({\mathrm{Me}}_{10}^{\mathrm{s}}\right) \) | Me^{s} changes from T _{0} to T _{1}, surgical effects measured over presurgical (T _{0}) to postsurgical period (T _{1}) |
Surgical upward movement of pogonion \( \left({\mathrm{Pog}}_{10}^{\mathrm{f}}\right) \) | Pog^{f} changes from T _{0} to T _{1}, surgical effects measured over presurgical (T _{0}) to postsurgical period (T _{1}) |
Postsurgical horizontal position of A point \( \left({\mathrm{A}}_1^{\mathrm{s}}\right) \) | Distance from A point to S-perpendicular plane measured at T _{1} |
Postsurgical vertical position of coronoid process \( \left({\mathrm{Cp}}_1^{\mathrm{f}}\right) \) | Distance from tip of coronoid process to FH plane measured at T _{1} |
Variables tested for multivariate regression model
T _{0} | T _{1} | T _{2} | ||
---|---|---|---|---|
Horizontal parameters | ||||
Maxilla | A^{s} | 62.5 (4.4) | 63.0 (4.5) | 62.6 (4.8) |
PNS^{s} | 20.0 (3.1) | 20.3 (3.1) | 20.8 (3.1) | |
Distal segment of mandible | B^{s} | 66.6 (7.0) | 58.2 (6.7) | 59.0 (7.3) |
Pog^{s} | 68.3 (7.5) | 61.1 (7.4) | 62.0 (7.9) | |
Me^{s} | 62.1 (7.4) | 54.4 (7.0) | 55.2 (8.1) | |
Proximal segment of mandible | Cd^{s} | −12.0 (3.3) | −11.2 (3.4) | −12.1 (3.3) |
Cp^{s} | 25.1 (3.7) | 25.7 (3.8) | 25.4 (3.7) | |
Dental parameters | U1^{s} | 69.3 (5.0) | 69.1 (5.2) | 68.8 (5.6) |
U1r^{s} | 58.3 (4.5) | 58.9 (4.8) | 58.8 (5.1) | |
L1^{s} | 70.7 (6.6) | 62.1 (5.6) | 64.5 (5.8) | |
L1r^{s} | 63.7 (7.2) | 55.4 (6.8) | 55.4 (7.3) | |
U6^{s} | 43.3 (4.2) | 43.5 (4.7) | 42.9 (4.9) | |
L6^{s} | 47.1 (17.6) | 38.8 (14.4) | 40.2 (15.4) | |
Vertical parameters | ||||
Maxilla | A^{f} | 31.2 (3.3) | 28.2 (3.5) | 27.8 (3.4) |
PNS^{f} | 24.9 (2.8) | 20.2 (3.9) | 20.0 (3.8) | |
Distal segment of mandible | B^{f} | 77.9 (6.5) | 75.0 (5.4) | 75.2 (7.5) |
Pog^{f} | 91.8 (8.0) | 88.1 (6.6) | 86.0 (7.1) | |
Me^{f} | 98.3 (8.1) | 94.3 (6.6) | 92.6 (7.3) | |
Proximal segment of mandible | Cd^{f} | 2.6 (2.0) | 3.4 (2.4) | 2.5 (2.5) |
Cp^{f} | 9.8 (4.8) | 11.3 (4.6) | 8.6 (4.7) | |
Dental parameters | U1^{f} | 55.2 (5.1) | 53.4 (4.7) | 53.5 (4.7) |
U1r^{f} | 34.3 (4.2) | 31.3 (3.8) | 31.3 (3.8) | |
L1^{f} | 55.6 (5.2) | 52.4 (4.3) | 51.1 (4.7) | |
L1r^{f} | 74.8 (6.1) | 71.5 (5.1) | 70.3 (5.5) | |
U6^{f} | 47.6 (4.4) | 44.1 (4.3) | 43.5 (4.5) | |
L6^{f} | 54.0 (18.6) | 50.7 (17.3) | 48.8 (16.6) | |
Occlusal vertical dimension | VD | 11.8 (3.3) | 9.9 (1.9) | 8.2 (1.3) |
All variables at each time point were investigated for construction of the PLS-PM for verification of the effect of the VD on the final setback of the mandible. Using PLS-PM, we tested various possible pathways by which the VD may affect the final mandibular setback extent. In the PLS-PM framework [11], the path modeling is composed of the measurement model (the outer model) and the structural model (the inner model) [12], wherein the predictor variables (\( {\mathrm{B}}_{10}^{\mathrm{s}},\kern0.5em {\mathrm{Me}}_{10}^{\mathrm{s}},\kern0.5em {\mathrm{A}}_1^{\mathrm{s}},\kern0.5em {\mathrm{Cp}}_1^{\mathrm{f}},\kern0.5em \mathrm{V}{\mathrm{D}}_{10} \) from the Lee study [9]) consisted of the measurement components or, equivalently, the manifest variables (MVs). Meanwhile, the latent variables (LVs) LV_{1}, LV_{10}, LV_{overall}, and LV_{setback,} which conceptualize the various postsurgical physiologic responses to surgery and orthodontic treatment that ultimately influence the final setback amount of the mandible, were considered in following the protocol of path modeling [10]. As for the outer model, wherein the causal relationships between a latent variable and manifest variables as their observed indicators are specified [13] as a formative outer model [12], a latent variable is defined as a linear combination of its corresponding manifest variables [11, 12]. The inner model is composed of LV_{1}, LV_{10}, LV_{overall}, and LV_{setback}, wherein the pattern of the relationship of an LV to other LVs can be expressed as a linear combination of those LVs that are relevant to it. In particular, LV_{setback}, which is equivalent to the absolute value of the final mandibular setback extent, was expressed as a linear combination of all other LVs. Since there is as yet no generally accepted model-fit index in the PLS-PM, a global criterion for goodness-of-fit (GoF) suggested by Tenenhaus et al. [6] was used to evaluate the prediction performance of the model, along with the R-square values observed within the framework of the inner model. For statistical analysis of the multivariate regression and the PLS-PM, the language R (Vienna, Austria), an open-source software program for statistical computation, was used.
Results
Summary statistics for outer model of derived partial-least-square path modeling (PLS-PM)
Latent variables | Weights | Std (weights) | Communality | Redundancy | |
---|---|---|---|---|---|
LV_{10} | \( {\mathrm{B}}_{10}^{\mathrm{s}} \) | 0.6438 | 0.991 | 0.9819 | 0 |
\( {\mathrm{Me}}_{10}^{\mathrm{s}} \) | 0.3723 | 0.973 | 0.9458 | 0 | |
LV_{overall} | VD_{10} | −0.0165 | −0.522 | 0.2729 | 0.2679 |
\( {\mathrm{B}}_{10}^{\mathrm{s}} \) | 0.5436 | 0.982 | 0.9639 | 0.9463 | |
\( {\mathrm{Me}}_{10}^{\mathrm{s}} \) | 0.4298 | 0.964 | 0.9287 | 0.9117 | |
\( {\mathrm{A}}_1^{\mathrm{s}} \) | 0.1177 | 0.176 | 0.0308 | 0.055 | |
\( {\mathrm{Cp}}_1^{\mathrm{f}} \) | 0.774 | −0.703 | 0.4944 | 0 | |
LV_{1} | \( {\mathrm{A}}_1^{\mathrm{s}} \) | −0.7146 | 0.638 | 0.4068 | 0 |
\( {\mathrm{Cp}}_1^{\mathrm{f}} \) | 0.774 | −0.703 | 0.4944 | 0 |
Correlations between latent variables (LVs)
LV_{10} | LV_{overall} | LV_{1} | LV_{setback} | |
---|---|---|---|---|
LV_{10} | 1.000 | 0.991 | 0.182 | 0.898 |
LV_{overall} | 0.991 | 1.000 | 0.309 | 0.925 |
LV_{1} | 0.182 | 0.309 | 1.000 | 0.409 |
LV_{setback} (absolute value of final setback of B-point = final setback amount) | 0.898 | 0.925 | 0.409 | 1.000 |
Summary statistics for inner model of derived PLS-PM
Model summary | |
---|---|
Goodness-of-fit (GoF) | 0.7236 |
LV_{overall} | |
R ^{2} | 0.9818 |
Intercept | 0 |
Path loading from LV_{10} | 0.9908 |
LV_{setback} (absolute value of final setback of B point = final setback amount) | |
R ^{2} | 0.8731 |
Intercept | 0 |
Path loading from LV_{10} | −0.9914 |
Path loading from LV_{overall} | 1.9065 |
Path loading from LV_{1} | 0.0013 |
Discussion
The surgery-first-orthognathic approach is characterized by minimal presurgical orthodontic treatment and orthognathic surgery followed by postsurgical orthodontic treatment. This application has recently been emphasizing its advantages, which include increased patient cooperation, effective compensation, and a shortened treatment period. However, because presurgical orthodontic treatments such as dental decompensation and arch coordination are rarely performed in the surgery-first-orthognathic approach, postsurgical occlusal instability clinically leads to more severe forward mandibular postoperative movement than in conventional surgical orthodontic treatment for skeletal class III deformity.
Our study was triggered by these questions: What variables (CBCT-generated cephalometric measurements) account for the final mandibular setback movements? How does postsurgical occlusal vertical dimension (VD) affect it?
To answer these questions, we applied PLS-PM analysis to the assessment of the treatment outcome for class III SFA cases. From this modeling, we confirmed that the PLS-PM as derived in our study signified the effect of occlusal VD on the extent of final mandibular setback and that an increase in VD leads to a decrease in the absolute amount of the final setback and, ultimately, more severe postsurgical skeletal changes (postsurgical relapse) (Fig. 2).
Tu and co-workers introduced a novel approach to high correlations among the variables using PLS and path-modeling analysis in periodontal research. PLS analysis was used for providing a simple relationship among multiple measures with two or more variables [14, 15]. It could be used for successfully summarizing the inter-correlations among many variables obtained from the analysis, such as the cephalometric analysis data. Lowe and co-workers used PLS analysis to assess the interrelations between obstructive sleep apnea (OSA) outcome variables and computer tomographic, cephalometric, and demographic predictor variables [8].
In the present study, \( {\mathrm{B}}_{10}^{\mathrm{s}},\kern0.5em {\mathrm{Me}}_{10}^{\mathrm{s}},\kern0.5em {\mathrm{A}}_1^{\mathrm{s}} \) and \( {\mathrm{Cp}}_1^{\mathrm{f}} \), along with VD_{10,} consisted of MVs, which are observable values by definition in the PLS-PM framework (Table 3, Fig. 2), as well as the LVs LV_{1}, LV_{10}, LV_{overall} and LV_{setback} and their presumed interrelationships (Tables 3 and 4, Fig. 2). Lee et al. built the multiple regression models for the estimation of the final mandibular extent in class III SFA cases. From their study, we re-analyzed these data for this research. From the previous study, the predictors \( \left({\mathrm{B}}_{10}^{\mathrm{s}},\kern0.5em {\mathrm{Me}}_{10}^{\mathrm{s}},\kern0.5em {\mathrm{A}}_1^{\mathrm{s}},\kern0.5em {\mathrm{Cp}}_1^{\mathrm{f}},\kern0.5em \mathrm{V}{\mathrm{D}}_{10}\right) \) identified in the general multiple regression model for all 40 patients consisted of the measurement components or, equivalently, the manifest variables (MVs) [9]. The other variables were not significant for predictors in the general model, as Lee and co-workers [9] had already reported. The LVs LV_{1}, LV_{10}, LV_{overall}, and LV_{setback} were not arbitrary but conceptualized the various postsurgical physiologic responses to surgery and orthodontic treatment that ultimately influence the final setback amount of the mandible [11]. These variables were used to evaluate the associations between these variables and the final mandibular setback extent, to determine which variables account for the final mandibular setback extent.
The PLS-PM as derived in our study signified the effect of occlusal vertical dimension on the extent of final mandibular setback (stability of the mandible). As depicted in Fig. 2, an increase in VD_{10} leads to a decrease in the value of LV_{overall}, which in turn reduces the value of LV_{setback}. The result figure (Fig. 2) explains a decrease in the absolute amount of the final setback and, ultimately, more severe postsurgical skeletal changes (postsurgical relapse). In the model derivation of PLS-PM, the LVs are presumed to represent patterns of physiologic responses after the surgery until the removal of orthodontic appliances, which may or may not be in favor of the expected SFA outcome. Those predictors were manually categorized, based on their temporal dimensions according to either the postsurgical position (T _{1}) or the amount of surgical movement (∆T _{1} − T _{0}), as LV_{1} or LV_{10}, respectively. The underlying physiologic response represented as LV_{1} is likely to involve factors dependent on the postsurgical skeletal positions of the maxilla and proximal segment, apart from the movement of the distal segment, while the physiological response represented as LV_{10} is solely dependent on the amount of horizontal setback of the distal segment of the mandible. Among those presumably related postsurgical factors such as the adaptation or healing process of the masticatory muscles or the change of occlusion due to surgery and orthodontic treatment, the question as to what constitutes LV_{1} and LV_{10} remains and should be studied further in subsequent research.
As for the outer model, the MVs of \( {\mathrm{B}}_{10}^{\mathrm{s}} \) and \( {\mathrm{Me}}_{10}^{\mathrm{s}} \) were presumed to cause LV_{10}, while those of \( {\mathrm{A}}_1^{\mathrm{s}} \) and \( {\mathrm{Cp}}_1^{\mathrm{f}} \) were presumed to cause LV_{1}, and those of \( {\mathrm{B}}_{10}^{\mathrm{s}},\ {\mathrm{Me}}_{10}^{\mathrm{s}},\ {\mathrm{A}}_1^{\mathrm{s}},\kern0.5em {\mathrm{Cp}}_1^{\mathrm{f}} \), and VD_{10} to cause LV_{overall}, in the formative sense; meanwhile, the extent of final mandibular setback \( \left({\mathrm{B}}_{20}^{\mathrm{s}}\right) \) was presumed to be caused by LV_{setback} in the reflective sense (Fig. 2) [11]. For the selection of the inner model, where the interactive relationships between LVs should be specified, various possible interactive mapping patterns were tested, and the finalized pathway was chosen based on the R-squares of \( {R}_{{\mathrm{LV}}_{10\kern0.5em \to \kern0.5em 1}}^2=\kern0.5em 0.9818 \) (LV_{10} effect on LV_{1}) and \( {R}_{{\mathrm{LV}}_{1,\kern0.5em 10,\kern0.5em \mathrm{all}\kern0.5em \to \kern0.5em \mathrm{setback}}}^2 = 0.8731 \) (LV_{1}, LV_{10}, and LV_{all} effects on LV_{setback}), with the acceptable GoF value of 0.7236 (Tables 4 and 5). In the finalized PLS-PM, an increase in VD_{10} was found to decrease the absolute value of the final setback amount of the mandible, in the LV_{all} pathway, as reflective of the postsurgical physiological responses to both surgery and orthodontic treatment, which in turn can be interpreted as an increase in postoperative mandibular changes.
The application of the surgery-first approach (SFA) has recently been reported, with its advantages (increased patient cooperation, effective compensation, and a shortened treatment period) [13–17]. However, orthodontists and oral surgeons often encounter postsurgical occlusal instability, induced from the premature contacts in SFA cases [16–19]. From the current literature and clinical experience, we hypothesized that these postsurgical changes in occlusal vertical dimension might be related to postsurgical skeletal changes (postsurgical relapse). To support the clinical observations and to detect collinearity between measurements, we adopted the partial-least-square path-modeling approach for this study. In clinical dental research, the data might be related to each other. However, we have reviewed the statistical problems such as collinearity. The deductive inference from the clinical research without considering this could sometimes be different from clinical observations, or an unclear conclusion, could be drawn. We attempted to apply the PLS-PM method to support the clinical observations with their interactions. This inference could provide clinicians with clearer cause-and-effect information. Unfortunately, this result was from one of many models with our defined latent variables. As for the shortcomings of our study, first, it was based on a 2-dimensional analysis. Therefore, for improved path modeling, a 3-dimensional analysis of postsurgical skeletal stability should follow this study. At this point, further research is required for better explanations and manifesting variables.
Conclusions
For the class III SFA, the present study focused on which variables were related and how the occlusal vertical dimension was related to the final mandibular setback movement. To resolve the issue of collinear cephalometric data, we adopted PLS-PM to assess orthodontic treatment. From PLS-PM, we concluded that the more increased the occlusal vertical dimension after surgery, the more changeable the B point position at the posttreatment stage. PLS-PM could be a useful statistical tool to explain the correlation among the variables from cephalometric analysis. However, as sample size increases, PLS becomes less biased. PLS-PM could be used to draw inferences about variables when sample sizes are large. Therefore, a multi-center approach is required to further validate our results for the clinical confirmation of SFA cases.
Declarations
Funding
This study was supported by a 2-year research grant of Pusan National University.
Authors’ contributions
NRK, SBP, JL, and YIK conceived, designed, and coordinated the study and collected the data. YKC, SMS, and YSC undertook the statistical analysis. All authors helped to complete the manuscript and approved the final manuscript.
Competing interests
The authors declare that they have no competing interests.
Ethics approval and consent to participate
This study was reviewed and approved by the Institutional Review Board of Pusan National University Hospital (E-2014021).
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