The treatment of UA has been controversial and can be radical or conservative [1, 2, 9, 15, 17,18,19]. Radical approaches can be achieved by segmental or marginal resectioning of the lesion, followed by insertion of reconstructive plates [1, 9]. Conversely, conservative treatments comprise enucleation, enucleation followed by application of Carnoy’s solution, or marsupialization followed by enucleation [1, 2, 9, 16, 20]. No adequate evidence proves which treatment modality is the most effective, and many reasons exist for this practical variability and controversy. Because of the relative rarity of this tumor, a definitive conclusion for this debate is difficult to reach [9].
One of the factors that can determine the effectiveness of a treatment is the recurrence rate, which varies with the different types of ameloblastoma [17]. UA is less aggressive than the solid type but has the potential for recurrence [19]. The reported recurrence rate after treating UA ranges from 10 to 25% [9]. According to many studies, the recurrence rate after radical treatment is lower than that after conservative treatment [1, 4, 9, 19, 21]. According to Lau and Samman, Enucleation alone yielded the highest recurrence rate among treatments (30.5%), while the lowest (3.6%) was observed with resection [9]. Seintou et al. reported a recurrence rate of 29.4% after enucleation or excision, and all recurrent cases were related to the conservative approach with enucleation or excision [1]. No recurrence was observed after resection. Sampson and Pogrel reviewed the records of 26 patients referred for management of mandibular ameloblastoma and reported that all patients treated with curettage alone developed recurrence [4].
It is clear that if an adequate bone margin is removed, the chances of recurrence are expected to be low. However, a balanced judgment is required when selecting this treatment option so that maximum success does not lead to overtreatment [9]. Despite the low recurrence rates of resection, there are reasons why radical resectioning of an ameloblastoma in children is often avoided [17]. The treatment of UA in children is complicated because of three factors: (1) continuing facial growth and different bone physiology (more cancellous bone, increased bone turnover, and reactive periosteum), (2) presence of unerupted teeth, and (3) difficulty in the initial diagnosis [1]. Radical surgery is associated with deformity, dysfunction, and numerous complications, including removal of teeth, masticatory dysfunction, and abnormal jaw movement, even after successful reconstruction. Particularly in young patients in the developmental period, the lack of mandibular growth can cause severe facial deformity, which directly influences quality of life [1, 2, 9, 15, 16]. Tanaka et al. demonstrated that minimal surgical treatment should be the first choice procedure for any case of oral and maxillofacial benign tumors in children [14]. Therefore, despite a high success rate for the resection of UA, more conservative treatments have been recently favored [6, 12, 13, 20, 22, 23].
UA’s biologic behavior is considered to be less invasive, and it responds more favorably to conservative treatment than a multicystic ameloblastoma [18]. Therefore, conservative therapy was performed in our patient. We used marsupialization as an initial treatment of UA to minimize the tumors’ volume, and after they regressed in size, they were enucleated.
The aim of marsupialization is to reduce the size of the tumor so that a less extensive surgery is required [23, 24]. The decompression of the internal contents by marsupialization promotes remodeling of bone and osteogenesis [2, 9]. The benefits of decompression are maintenance of pulp vitality, preservation of the inferior alveolar nerve or maxillary sinus, preservation of the mandibular contour and growth, prevention of fracture of the jaw, and low risk for recurrence [20, 25]. According to a systematic review by Lau and Samman, when marsupialization was performed with or without further treatment, the recurrence rate (18%) was lower than that of enucleation alone (30.5%) [9]. The outcome of marsupialization is affected by various factors such as age, technique of marsupialization, removal of solid growths during incisional biopsy, close radiographic follow-up, and effectiveness of enucleation after marsupialization [23]. Nakamura et al. who evaluated the effectiveness of marsupialization for cystic ameloblastomas, concluded that marsupialization was useful as a preliminary treatment of the tumor [16, 20]. They further reported that the effect of marsupialization mainly depends on the following factors: (1) potential for new bone formation, (2) technique of marsupialization, and (3) growth characteristics of the tumor. The potential for bone formation is mainly influenced by the patient’s age. Marsupialization appears to be more effective in young patients, particularly those in the second decade of life. In contrast, lesions could not be easily decompressed in patients who were aged > 60 years. Accordingly, a longer time is required for marsupialization to be effective in older patients [16].
During surgery, the involved teeth are usually extracted together with the tumors to not only completely remove the tumors, but also prevent their recurrence. However, tooth loss can result in functional and esthetic disturbances. Furthermore, prosthodontic treatments are generally difficult in young adolescents because of their dental and skeletal growth. If impacted or involved teeth within ameloblastomas can be preserved and if functional occlusion can be obtained, the patients’ quality of life will significantly improve, particularly in young patients [7].
Marsupialization therapy is usually performed for preserving the involved teeth and promoting eruption of the tooth within the lesion [7, 26, 27]. Hyomoto et al. found that the eruption potential is closely related to root formation [26]. An impacted tooth with an incomplete root and with an open apex has a considerable potential to erupt. Sano et al. reported the spontaneous eruption of an involved second molar in UA of the mandible after marsupialization followed by enucleation and believed that spontaneous eruption and favorable occlusion were obtained for four reasons [7]. First, the lesion was histologically diagnosed as a tumor without infiltration into the surrounding bone. Second, marsupialization reduced the cavity of the unicystic tumor. Third, the impacted second molar was in a condition without complete root formation and with open apices. Fourth, the second molar, rather than being adjacent to the other teeth, had sufficient eruption space.
In our case, the eruption of the mandibular second molar on the affected side was disturbed by the tumor. The impacted second molar naturally erupted after reducing the tumor volume from marsupialization. We eventually decided to keep the second molar, although the third molar had to be extracted.
Conservative treatment appears to be preferable in the younger age groups because it offers a better quality of life; however, the recurrence rate remains high [1]. Therefore, during surgical treatment after marsupialization, careful attention should be given to removing the tumor by sufficient curettage of surrounding tissues [16]. Moreover, long-term follow-up is important for conservative treatment of UA because > 50% of recurrences occur within 5 years of the treatment [1, 19]. Scariot et al. also believe that a more aggressive surgical approach should be considered when the condition recurs more than twice or when required by the patient [17]. Tanaka et al. argue that in cases of recurrence, a second surgery should be more extensive, but overtreatment should be avoided in children [14].
In conclusion, conservative treatment for UA in young patients has more advantages. Our young patient who was treated by conservative management did not have any complications, and the condition was well maintained, with no signs of recurrence. Spontaneous eruption occurred after marsupialization without the extraction of the involved second molar. This tooth functions well without the need for a root canal.